Good To Know Every patient with type 2 diabetes needs to be aware of an important new study from Israel that shows just how crucial it is for diabetics to get ample amounts of vitamin E. If you're a diabetic, you MUST talk to your doctor about this study. And if you have a friend or loved one who has type 2 diabetes, I urge you to share this e-Alert with them. Cigarette smoke, excessive alcohol intake, radiation, environmental pollutants, highly refined junk food - these are some of the most common factors that prompt oxidative stress in the body, increasing the risk of a wide range of health problems. According to a new study published online in the Journal Arteriosclerosis, Thrombosis, and Vascular Biology, an antioxidant protein known as haptoglobin helps prevent inflammation in artery walls and is a key element in preventing cardiovascular events such as heart attack in type 2 diabetes patients. Unfortunately, some diabetics have a haptoglobin gene called Hp 2-2 that's been linked to poor antioxidant protection and a greater risk of heart problems. A group of Israeli researchers conducted a study to test their hypothesis that vitamin E supplements might boost antioxidant protection and reduce cardiovascular events in diabetics with Hp 2-2. STUDY PROFILE - Researchers recruited more than 1,400 subjects over the age of 55
- Each subject had type 2 diabetes and the Hp 2-2 gene
- Subjects were randomly divided into two groups to receive either 400 IU of vitamin E daily, or a placebo
- At 18 months, when researchers first evaluated subjects' medical records, rates of heart attack, stroke, and death due to cardiovascular events were about twice as high in the placebo group compared to the vitamin E group
- The study was terminated early so as not to withhold vitamin E supplementation from subjects in the placebo group
The Israeli researchers note that the Hp 2-2 gene is present only in a small percentage of the population. But given the importance of vitamin E and the fact that no adverse effects were reported over the 18 months of this study, there would appear to be no downside for diabetics who supplement with vitamin E, provided they first discuss supplement usage with their doctors. So…how much is enough? In a recent e-Alert I told you about a Vanderbilt study that showed how subjects at high risk of heart disease who took 3,200 IU of vitamin E for 20 weeks significantly lowered levels of a biomarker that measures oxidation of fats. Obviously, 3,200 IU a huge daily dose, but in that same e-Alert HSI Panelist Allan Spreen, M.D., explained that reliable research shows that taking large doses of E is not dangerous. Dr. Spreen's general recommendation: 400 IU for everyone, 800 for those at risk of heart disease. As always, any discussion of vitamin E supplementation requires this note: D-alpha tocopherol is an acceptable form of E (AVOID dl-alpha tocopherol, which is synthetic and shouldn't be taken internally), but an E supplement with the full spectrum of mixed tocopherols will probably produce the best results. And one final tip (especially for diabetics): In 2003 I told you about a Danish study in which vitamin E (680 IU daily) and vitamin C (1,250 mg daily) taken together reduced concentrations of a liver protein that can damage the kidneys. Source:
"Vitamin E Supplementation Reduces Cardiovascular Events in a Subgroup of Middle- Aged Individuals With Both Type 2 Diabetes Mellitus and the Haptoglobin 2-2 Genotype. A Prospective Double-Blinded Clinical Trial" Arteriosclerosis, Thrombosis, and Vascular Biology, Published online ahead of print 11/21/07, atvb.ahajournals.org | 
